Y-chromosome microdeletion and male infertility: a systematic review
نویسندگان
چکیده
منابع مشابه
Correlation between Y chromosome microdeletion and male infertility.
Dyszoospermia due to genetic factors is the leading cause of male infertility. To explore the correlation between azoospermia factor (AZF) microdeletion of the Y chromosome and male infertility, we evaluated AZF microdeletion on the long arm of the Y chromosome in 166 infertile males and 50 fertile males using multiplex polymerase chain reactions amplification and gel electrophoresis. The resul...
متن کاملY chromosome and male infertility.
Recent genome analysis of the Y chromosome has increased the number of genes found on this chromosome markedly. Many of these genes in the part of the Y chromosome that does not undergo recombination with the X chromosome are members of gene families. Evolutionary considerations imply that genes on the Y chromosome will degenerate unless they have male advantageous or female deleterious functio...
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As you know, for penile erection, a sufficient amount of testosterone-induced nitric oxide is needed in the smooth muscle of the penile arterial wall. With aging, LOH syndrome and so on, the serum testosterone level decreases, resulting in a decline of penile erectile function. Furthermore, it is known that the enzyme PDE5 in the penile artery wall also inhibits that function. Even so, it may b...
متن کامل[Y chromosome microdeletions in male infertility].
A genetic basis of infertility may exist in many men currently classified as having idiopathic infertility. Approximately 7% of infertile men harbour submicroscopic deletions of the Y chromosome that are not detectable on routine karyotype. Two candidate gene families, namely the RNA-binding motif-containing gene family, and the deleted-in-azoospermia gene family, have been cloned by deletion m...
متن کاملPnm-22: Obesity and Male Infertility: A Systematic Review
a:4:{s:10:"Background";s:223:"In today's worlds of advanced technology, obesity phenomenon, more than whatever seen before, is a risk and health- threatening factor. Recent studies show that there is a relation between obesity and infertility in men.";s:19:"MaterialsAndMethods";s:178:"This paper is written with an overview of related articles published in Sciencedirect, Pubmed,SID and Iranmedex...
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ژورنال
عنوان ژورنال: International Archives of Medicine
سال: 2015
ISSN: 1755-7682
DOI: 10.3823/1788